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Blood pressure and heart rate were monitored noninvasively using BR-102 plus ABPM (ambulatory blood pressure monitoring) system (Schiller, Baar, Switzerland)

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There are several isoforms of sodium-glucose cotransporters expressed in different tissues, and their regulation is complex

They found that although many regions of the brain have GLP-1 receptors, when the mice were dosed with the GLP-1R agonist semaglutide, the semaglutide ended up on only a fraction of the mouse brains GLP-1 receptors, mainly in the hypothalamus, brainstem, and septum