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The exact time of the procedure of injection will be recognized by the quantity of glutathione that is utilized
It is also important to note that the test may result in other dermatological lesions in addition to papules, vesicles and bullae.55 The method consists of occluding the medication, previously diluted in a medium (Vaseline, water), on the skin, together with the vehicle alone, used as control.5557 In Europe, Canada and the United States, there are more commercially available preparations for testing drugs, but in Brazil, most substances are tested in accordance with the European guidelines: (i) Testing the commercialized drug diluted at 30% or (ii) Preferably using the pure substance at 10%, unless there is concentration information specific for the substance available in the literature.5557 There is no published study in which the drugs suspected of causing DRESS have been tested at different concentrations and vehicles in the DPTR, in a considerable number of patients, and with fully specified results.5557 The literature does not provide an indication of the optimal or preferred concentrations and vehicles for DPTR with specific drugs, either.56 In intravenous preparations, it is recommended to use the undiluted medication powder for the test
doi: 10.1056/NEJMcibr035136 248
2011;6:e18046 Pemble SE, Wardle AF, Taylor JB
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