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One important distinction: tirzepatide consistently produces greater percentage weight loss than semaglutide in head-to-head comparisons
While there arent currently many prescription medications that directly affect glutamate, there are several companies investigating its potential for treating severe treatment-resistant depression, substance abuse, and obsessive-compulsive disorder
Smaller meals, eating more slowly, lighter and less greasy foods, and steady hydration all help
Metformin commonly causes mild gastrointestinal upset initially, while GLP-1 medications may cause nausea, particularly during dose escalationthough nausea typically decreases after 2-3 weeks as the body adjusts
Why GLP-1s Changed the Conversation The reason GLP-1s feel like such a big shift is that they address something diet culture has always been terrible at discussing honestly: appetite
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