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In the STEP 1 trial, adults taking Wegovy 2.4 mg weekly achieved an average weight loss of 14.9% of their baseline body weight over 68 weeks, compared to just 2.4% in the placebo group

Despite challenges in terms of efficacy, selectivity, and safety, several classes of novel synthetic DNL inhibitors are currently in the clinical stage of development and may form the basis of a novel class of therapies (142)

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