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Weeks 1-4 Starting dose Weeks 5-8 First increase Weeks 9-12 Therapeutic level Weeks 13-16 Near target Week 17+ Full dose Side Effects & Safety Most side effects are temporary and manageable
The balanced triple-agonist profile is hypothesized to combine glycemic control (GLP-1/GIP) with increased energy expenditure (glucagon) in metabolic research models
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Most patients experience improvement as their bodies adjust to the medication over 48 weeks, though some individuals may have persistent symptoms requiring intervention
Important safety considerations include the risk of pancreatitis (seek medical attention for severe abdominal pain), gallbladder disease, acute kidney injury with dehydration, and potential effects on diabetic retinopathy
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