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Some researchers believe this activation may lead to an increased release of inositol triphosphate (IP3) and diacylglycerol (DAG)

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There are many foods rich in vitamin B12, such as: Dairy Fish Beef Chicken Fortified cereals or yeast Eggs Yet even though many people eat a diet rich in these foods, a significant number of individuals may suffer from a deficiency in vitamin B12 caused by gastrointestinal issues such as low levels of stomach acid

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All these indicated that stress factors, actively growing tissues as well as normal physiological and metabolic changes could induce the expression of APX genes in tissue-dependent way