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In the context of GLP-1 receptor biology, where chronic high-level receptor activation can lead to tachyphylaxis (reduced responsiveness over time), partial agonism could potentially maintain a more sustained therapeutic effect over extended treatment periods

The upper arm tends to be more visible than the abdomen or thigh for injection site reactions like redness or bruising

For years, researchers suspected it existed naturally in the human body, and in 2017, Epitalon was detected for the first time in physiological pineal gland extract, confirming it as an endogenous compound

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Mechanistically the peptide is hypothesised to act as a 'gene-regulatory short peptide': because of its small size it is proposed to reach the nucleus intact and to bind DNA at specific motifs