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In patients with AITD, autoreactive lymphocytes infiltrate the thyroid parenchyma, where they recognize thyroid antigens: Tg, TPO, TSH-R, and the sodium iodide symporter (19, 20)
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A major extracellular enzyme, GPX3, is also found in the cytoplasm and plasma membranes of the mammalian kidney, epididymis, heart, lung, liver, brain, adipose tissue, mammary gland, and gastrointestinal tract (Nirgude and Choudhary, 2021)
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