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(Peptide Sciences) While senescence is protective in acute contexts (e.g., preventing malignant transformation, wound repair), the accumulation of senescent cells over time is detrimental: They occupy tissue space and resources, impairing progenitor cell function
There are no symptoms or negative effects in early stages
That is, biologics/small molecule agent combination therapy, to the extent that it reduces both immunogenicity and a high inflammatory burden, has the potential to minimize steroid exposure, induce remission, and avoid colectomy by facilitating a safe transition to maintenance therapy
ABSTRACT: Since the approval of the first dipeptidyl peptidase-4 (DPP-4) inhibitor in the United States in 2006, the use of these agents as second-line oral antihyperglycemic therapy in type 2 diabetes management has been established
These were predominantly dose-dependent and most prominent during dose escalation
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