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Andreassen and colleagues (J Med Chem, 2021) reported a design campaign that combined sequence substitutions to suppress fibrillation with a fatty-acid acylation that promotes albumin binding, yielding a molecule with a much longer reported plasma half-life in their preclinical models
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For example, when it binds the receptors and smooth muscle in vasculature, we get improvements in blood pressure
Dry eye disease in patients with type II diabetes mellitus: a retrospective, population-based cohort study in Taiwan
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