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Also, due to the important role of endothelial dysfunction in CVD, the effects of GLP-1RA on flow-mediated vasodilation (FMD) in patients remain to be investigated for their contribution to the CVD actions of GLP-1RAs

[1] [2] Women using oral hormonal contraceptives should use a non-oral method or add a backup method of contraception for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase, as tirzepatide may reduce the effectiveness of oral contraceptives during these periods

It seems likely that GLP-1 receptor agonist drugs effects on the body are rather short-lived and not terribly important for weight loss

Even with a research history dating back to the 1970s, DSIP has somewhat fallen out of the scientific literature in the past 20-30 years, and much about its health applications is subject to debate

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