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General anesthesia can cause postoperative cognitive dysfunction (POCD) which can look and feel similar to dementia

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However, intense and prolonged physical activity can also lead to temporary depletion of Glutathione due to increased oxidative stress during exercise

Immunohistochemical analysis revealed that treatment with DAPA led to increased expression of Nrf2, HO-1, SLC7A11, GPX4 and FTH-1 as well as decreased expression of TFR-1 compared with the DN group and si-Nrf2 group (Fig