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The MariTide Phase 2 data presented in November 2024 were highly significant: MariTide demonstrated robust weight loss at 52 weeks with no plateau meaning continued weight loss trajectory at the end of the study period, unlike semaglutide and tirzepatide which show plateau effects and significant improvements in cardiometabolic parameters

However, FSP1 must be myristoylated and recruited to lipid membranes to execute its reductase function [83]