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To integrate possible mechanistic events, a unified proposal for the role of cuproptosis in Wilson disease is suggested: (1) Published data support that copper ions induce oxidative stress by generating ROS, including hydroxyl radicals and H 2 O 2 , via the Haber-Weiss and Fenton reactions [21,27,45-49,59,77,90-92]

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Brunner F, Kurmann M, Filippi A

It neutralizes free radicals, which are unstable molecules that can cause oxidative stress and damage your cells

The composition of MAMs includes: 1) Ca 2+ channels located on the ER or outer mitochondrial membrane, such as inositol 1,4,5-triphosphate receptor (IP3R) and voltage dependent anion channel 1 (VDAC l) (Furuichi et al