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The concerns about long-term safety are real and, so far, unresolved
We recently repurposed sertraline, an antidepressant that efficiently crosses the BBB, as a specific SHMT1/2 inhibitor with robust anti-cancer properties, effectively targeting ser/gly-dependent cancers in vitro and in vivo [33,34,35]
OI causes included: cytomegalovirus (45.4%), aspergillus and endemic mycoses (20.6%), disseminated candidiasis (10.8%), varicella zoster virus (12.7%), tuberculosis and non-tuberculous mycobacteria (4.4%) and other (4.2%)
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Furthermore, research suggests that PFAS require active transport during distribution, one class of transporters being organic anion transporting polypeptides (OATPs)
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