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Cytosolic and Chloroplastic DHARs Cooperate in oxidative stress-driven activation of the salicylic acid pathway
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T1D and CD T1D and CD have a complex mechanism (Shalimova et al., 2019) but share a disturbance in insulin secretion in blood and sensitivity in insulin receptor (IR) to activate oxidative stress (Newsholme et al., 2016) and inflammatory cascade that causes mitochondrial damage, especially in neuronal and dendritic processes in AD (Khan & Hegde, 2020)
Additional multi-agonist therapies (e.g., triple and higher-order receptor agonists) and expanded oral formulations are currently under investigation.[1] GLP-1 receptors are widely distributed in both central, vascular, and peripheral tissues, including regions of the brain involved in reward and motivation
doi: 10.1016/j.intimp.2024.112303 195 LiuXChenCZhuSLuoXGaoLHuZet al
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