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[15] Serious but infrequent events-such as angioedema, bronchospasm, hypotension, or urticaria-reflect IgE-mediated hypersensitivity and may require desensitization or substitution with hydroxocobalamin
R., Doran, E
This is the process known as oxidative stress
Splitting into twice-daily injections is reasonable at higher daily totals (e.g., 250 mcg AM + 250 mcg PM at a 500 mcg/day total)
Its usually not covered by insurance (since its considered elective), but most clinics offer memberships or packages to make regular treatments more affordable
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