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Notably, mPTP opening represents a critical decision point in cell fate: transient, low-conductance openings serve physiological roles in Ca 2+ homeostasis, whereas sustained, high-conductance opening exceeding the point of no return inevitably leads to mitochondrial swelling, outer membrane rupture, and cell death via apoptosis or necrosis ( Concurrently, IR injury profoundly compromises microvascular integrity

10.15252/embj.2018101259 EMBO J

In such conditions, sweat combines with other irritants, aggravating skin issues

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This reduces the side effects substantially