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SELECT Trial Result: A primary cardiovascular end-point event occurred in 6.5% of semaglutide patients versus 8.0% of placebo patients a hazard ratio of 0.80, representing a statistically significant 20% reduction in major adverse cardiovascular events (MACE)

Crucially, Crat knockout experiments partially reversed these metabolic improvements, establishing CrAT-mediated SREBP1c inhibition as a key mechanism through which L-carnitine counteracts de novo lipogenesis