The earlier SUSTAIN dose-finding studies for diabetes (Nauck et al., Diabetes Care, 2016) tested multiple dose levels including 0.05 mg, 0.1 mg, 0.2 mg, 0.3 mg, and 0.4 mg daily (note: daily, not weekly) of oral semaglutide and found dose-dependent reductions in HbA1c and body weight at every dose tested
Metabolic improvements from tirzepatide persist as long as treatment continues
However, off-label use fueled by celebrities and social media is a growing concern
Retatrutide has shown strong weight loss results in early research, with people losing an average of 28.7% of their body weight over roughly 68 weeks at the highest studied dose
The concept of "circadian eating," which aligns meals with the bodys natural rhythms, has shown promise in reducing HbA1c levels and improving overall metabolic health