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OctoberDecember 2025: denosumab (MB09) Amneal and mAbxience are awaiting FDA approval of MB09, a biosimilar candidate for the RANK ligand (RANKL) inhibitor denosumab

Titration: Treatment usually starts at a low dose and gradually increases every few weeks to help minimize side effects and allow the body to adjust

Four Corners spent months speaking to dozens of medical practitioners, patients and pharmacists, collecting a trove of documents that tell a strange story