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Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation
Weeks 5-20: After five weeks, many patients increase their dosage
The primary pathway involves activation of GLP-1 receptors located in the myenteric plexus of the enteric nervous system, coupled to Gs protein subunits that activate adenylyl cyclase and increase cyclic adenosine monophosphate (cAMP) levels [14]
Redox Biology, 8 , 7990
Sun, X., Deng, Y., Fu, X., Wang, S., Duan, R., & Zhang, Y
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