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The distinction matters for modifier application and patient cost-sharing

J Physiol Pharmacol 64(4):439451 Tripathi K, Feuerstein JD (2019) New developments in ulcerative colitis: latest evidence on management, treatment, and maintenance

Although we cannot rule out that the increased production of ROS in 3D culture conditions may not be observed under hypoxia, it should be noted that hypoxia itself induces ROS production in numerous cell types, including tumor cells [39]