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Crucially, individuals in ADRD demonstrate marked impairments in cerebrovascular reactivity to CO 2 compared to controls (Glodzik et al., 2013
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However, we cannot rule out ROS-independent functions of GSH in B cells that contribute to our observed effects
Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC expression while inhibition of corticosterone synthesis using metyrapone reverses hypoxia induced downregulation of both Nrf2 and GCLC level
In addition, glutathione is clearly reduced in the aqueous humor of glaucoma patients with both IOP-dependent and IOP-independent disease subtypes
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