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Consistent with a protective role, endogenous FGF21 serum concentration may be elevated by up to 1020-fold in patients with NAFLD (62, 63), NASH (64), obesity (6466), type 2 diabetes (67), chronic kidney disease (68), diabetic nephropathy (69), atherosclerosis (70, 71), or coronary heart disease (72)

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In female patients, its been shown to increase sexual desire and arousal as well as decrease distress associated with sexual dysfunction (4)

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