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Experience employing dosing regimens from once-a-day to four-times-a-day, as well as studies in primate epilepsy models involving constant rate infusion, indicate that total daily systemic bioavailability (extent of absorption) is the primary determinant of seizure control and that differences in the ratios of plasma peak to trough concentrations between valproate formulations are inconsequential from a practical clinical standpoint

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This study proposes that elesclomol-induced cell death represents a unique form of copper-dependent cell death, laying the groundwork for the subsequent discovery of cuproptosis

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