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However, significant reductions in inflammation markers and tissue healing typically require 8-12 weeks of consistent treatment

This scoring system allowed for semi-quantitative evaluation of cartilage integrity based on macroscopic features such as softening, fibrillation, erosion, ulceration, and complete cartilage loss [1]

For exercise performance and VO2 max improvement, the evidence from human exercise studies suggests that MOTS-c's acute rise following high-intensity training is part of the adaptive signal driving mitochondrial biogenesis and cardiovascular remodeling