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10.1016/j.expneurol.2013.10.002 54 LimJ

The risk factors for a metabolic syndrome diagnosis include excess belly fat, high blood pressure, high blood sugar, and high cholesterol

Additionally, the interaction between NANOG, a gene associated with stem cells, and STAT3 increases MDR1 expression and the efflux of chemotherapeutic drugs, leading to chemoresistance development (70)