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and the biological pathways in which differential genes were involved included apoptotic process involved in development, extracellular structure organization, activation of MAPKK activity, apoptotic process involved in morphogenesis, positive regulation of coagulation, positive regulation of hemostasis, positive regulation of blood coagulation, regulation of apoptotic process involved in development, cell junction maintenance, and regulation of apoptotic process involved in morphogenesis
The EMPA-KIDNEY trial (NCT03594110) is similarly studying the effect of empagliflozin in patients with diabetic chronic kidney disease (DKD) or non-diabetic chronic kidney disease (CKD), and has a lower limit of inclusion, GFR at 20 mL/min/1.73m 2
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