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For a broader look at how long semaglutide remains good under various conditions, the timelines depend on which product you have and how you store it
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This is covered in detail in the maintenance section, but briefly: people who have established ketogenic metabolic adaptation while on semaglutide appear better positioned to maintain their weight loss after discontinuation than people who relied purely on drug-mediated appetite suppression
With structured resistance training, lean body mass loss can be reduced by 5095%
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