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Ultimately, TMAO is distributed throughout the body, being eliminated via the kidneys or accumulating in tissues (47)

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Moreover, adverse effects of tirzepatide, such as gastrointestinal issues, could limit patient tolerance and broader adoption

[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs

Their effect is independent of blood glucose levels