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(11) Their findings suggest an upward shift in IGF-1 from baseline values around 160 ng/mL to roughly 250265 ng/mL, which corresponds to an apparent 1.6-fold increase

Typically, exhausted T cells are characterized by a hierarchical loss of effector functions (e.g., cytokine production and cytotoxic activity) and proliferative potential, high and sustained expression of inhibitory receptors (e.g., PD-1, CTLA-4, LAG-3, Tim-3, CD39, CD103), and unique transcriptional and epigenetic programs [215, 216]