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This is a later sign, appearing when B12 deficiency has persisted for a long time
That puts it squarely in a regulatory gray area whereby it can be procured legally, but there is no standardization, potential for contamination, and unknown long-term effects
In practice, TB-500 remains outside FDA-sanctioned compounding and is sold only as an unregulated research chemical
Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity
10.1016/j.ccell.2018.08.016 151 YeungC
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