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In one study 10 , elderly mice treated with 5-Amino-1MQ showed: ~40% stronger grip strength in sedentary conditions ~20% improvement with exercise ~60% boost when combined with exercise + therapy This suggests powerful benefits for maintaining strength and resilience with age

Importantly, treatment did not negatively impact markers such as bone mineral density (BMD) or body weight in a manner inconsistent with healthy controls (Fawcett 2010)

But with the biological similarities between rodents and humans, this research presents a promising picture of how MOTS-c might impart the following health benefits:15 Improved metabolic function Recall that MOTS-c activates a pathway called AMPK that stimulates glucose uptake

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Doi:10.1155/2015/648108 Pickart L, Vasquez-Soltero JM, Margolina A