It has been reported that urolithin A also increased total GSH, lowered oxidative stress, and improved cardiac function in the myocardium of diabetic rats [174]
Beyond its pancreatic effects, GIP receptors are found in adipose tissue and the brain, where they are believed to play a role in regulating fat metabolism, energy storage, and energy expenditure
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A clinical trial published in 2022 found that an older GLP-1 drug called exenatide also reduced drinking among those who had both alcohol use disorder and obesity
This strategy may improve subjective tolerability for some individuals, especially during the titration phase when side effects are often most pronounced