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and Rondanelli, M
Furthermore, the strong sequence homology within the catalytic core contributes to substantial challenges in achieving isoform-selective inhibition and often results in off-target engagement, a major factor underlying the clinical failure of PDE-targeted therapeutics (Goff et al., 2009
Its this kind of precision and reliability that makes the KLOW peptide a favorite in labs experimenting with anti-aging solutions
Focusing on older women helps answer a neglected question in geroscience, since women shoulder a higher burden of dementia and live longer on average
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