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The addition of glucagon-receptor activity to the dual-incretin mechanism (already represented by compounds such as tirzepatide) is hypothesized in the literature to extend the molecule's effects on hepatic lipid handling and energy expenditure beyond what is observed with GLP-1/GIP co-agonism alone
Some people may experience side effects like stomach pain and diarrhea when taking more than 9 g per day
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Side Effects and Safety: What to Expect GLP-1 medications can cause side effects, particularly during initial titration
Special Considerations for Specific Groups Some people need different ways to use semaglutide
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