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Although description of gonorrhea-like symptoms dates back to ancient civilizations like the Romans, Jews, and Arabs, genomic analysis suggests that the modern gonococcal population originated much more recently, possibly in the 16 th century, and was subsequently spread globally (Golparian et al., 2020)
At 24 hours post-injury, Semax upregulated active CREB in subcortical structures while downregulating MMP-9 and c-Fos in adjacent cortical areas and reducing active JNK in both tissues
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