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June 04, 2021 Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF
Int J Mol Sci 24(4)
The biology behind it is not fully settled, but dose-response curves that peak and then fall off are common for signaling molecules, where too much of a stimulus can desensitize or overshoot the system it is meant to nudge
Most people reach their effective dose within 48 weeks and begin seeing accelerated weight loss once that dose is established
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