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Functional imaging studies show that GLP-1R agonists blunt neural responses to reward cues in the ventral tegmental area and nucleus accumbens, and retrospective and early prospective data link their use to reduced intake of alcohol and nicotine

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Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible

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