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Anyone using retatrutide particularly outside of a supervised clinical trial should disclose all supplements, including creatine, to their prescribing clinician or pharmacist to enable an individualised risk assessment

This keeps the work aligned with regulatory guidance while still allowing for detailed exploration of how the peptide behaves in various models

However, given the ubiquity of ER stress-related pathways and IR crosstalk mentioned above, diabetes-related IR is likely to be involved in the generation of ER stress in PD

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Acknowledgements Illustrations were created with Biorender