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The high neutrophil to lymphocyte ratio in critically ill patients, the intense neutrophil infiltration in pulmonary capillaries and into pulmonary alveoli, and the increased levels of circulating neutrophil extracellular traps (NETs) clearly show neutrophil involvement/activation favoring intense ROS production and oxidative damage caused by lipid peroxidation, and protein and DNA oxidation (Komaravelli and Casola, 2014

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Histone demethylase KDM3B enhances SLC7A11 expression by inhibiting H3K9 methylation [34]

However, these drugs have limitations, including potential side effects, immunogenicity, susceptibility to infections, and high costs

This effect has been noted in rat studies [4]