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Experimental frameworks assess nitric oxideassociated signaling, modulation of inflammatory mediators, and intracellular survival cascades including PI3K/Akt and ERK pathways within vascular cell models

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Effects of long-term TNF- inhibition in IMIDs Long-term effects on bone pathophysiology in inflammatory arthritides Along with interleukin-6 (IL-6), TNF- stimulates synovial fibroblasts to produce receptor activator of NF-B ligand (RANKL) promoting osteoclasts differentiation and activation [33]

Biochemistry 2007;46:5830-40

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