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Although -glutamyl-peptides per se did not directly protect cells against ferroptosis under cystine starvation, their biosynthesis consumes glutamate, an intracellular amino acid that was previously implied in ferroptosis induction via glutaminolysis 13

Tein I, De Vivo DC, Bierman F et al : Impaired skin fibroblast carnitine uptake in primary systemic carnitine deficiency manifested by childhood carnitine-responsive cardiomyopathy

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While this amplifies the effect, it doesnt necessarily increase the long-term risk if the protocol includes proper cycling and monitoring