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This makes injections highly effective for pernicious anaemia and other malabsorption syndromes, including post-gastrectomy states, Crohn's disease affecting the terminal ileum, and certain medications that interfere with B12 uptake

The dosage and frequency of therapy required depends on the clinical condition of the animal and the copper status, as assessed by blood and liver levels both before and after therapy

Epidemiologic studies have shown a link between vitamin B12 and folate deficiencies and increased metabolic risk

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