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We conclude that while a consensus in pharmacogenetic management of APAP in pediatric populations has not been achieved, a systems biology based strategy for comprehensively understanding the ontogenic regulatory pathway as well as the interaction between age and genetic variations are particularly necessary in order to address this question
The phase 3 TRIUMPH-4 trial confirmed these findings
More importantly, most of these inhibitors can cause hyperglycemia, a profound off-target effect, leading to drug intolerance and promoting tumor growth in pancreatic cancer patients
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