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Global Pharm Sci Rev V

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DNA damage repair: PARP1 consumes NAD+ to detect and repair DNA strand breaks

The intact BBB impedes the influx of most blood-borne substances from entering the brain

37 CONCLUSION In consideration of clinical trials published thus far, oral semaglutide has demonstrated efficacy in terms of A1C and weight reduction when used as an addon to a variety of background glucose-lowering regimens in patients with T2DM and inadequate glycemic control