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If you don't get enough vitamin B12, you might experience adverse side effects like numbness, tingling, and canker sores

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If improved health and vitality is what you're after, you should also aim to get plenty of B12 through your food, incorporating health-promoting fortified foods like nutritional yeast, natural fortified cereal, and fortified plant milks into your diet (and maybe a few vegan gummy vitamins on top to help with specific issues)

Therefore, any discussion of synergy is largely theoretical and based on extrapolation from individual studies

at least 2000 mcg daily) oral supplementation instead of continuing parenteral supplementation, but