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18 However, its rapid hydrolysis by intestinal lactase and SGLT1 inhibition causing diarrhea limited its clinical use
As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures
A substance that binds to heavy metals is a chelator, and chelation transports them out of the body
M., DeSilva, D., Pickart, L., & Aust, S
Kalyani RR, Tra Y, Yeh HC, Egan JM, Ferrucci L, Brancati FL
