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This suggests that nutrient-induced GLP-1 secretion was inhibited by pasireotide via SSTR-Gi-dependent inhibition of cAMP levels
To validate this structural effect, it will be necessary to use an animal OA rodent model, such as the surgical destabilization of the medial meniscus (DMM), which is a more acceptable and suitable model to study the effects of liraglutide on cartilage degradation 56
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